Bonds et al. examined the relationship between diabetes and Alzheimer’s disease and found that a protein called caveolin-1 (Cav-1) is depleted in the temporal lobe of humans with diabetes and in a diabetic mouse model. Depletion of Cav-1 causes the upregulation of amyloid precursor protein and b-amyloid levels.
Importantly, restoring Cav-1 levels in mice reduced Alzheimer’s pathology and improved learning and memory deficits, revealing a potential mechanism responsible for the increased risk of Alzheimer’s disease in this population.
Society for Neuroscience
Journal reference:
Bonds, J.A. et al. (2019) Depletion of Caveolin-1 in Type-2 Diabetes Model Induces Alzheimer's disease Pathology Precursors. Journal of Neuroscience. doi.org/10.1523/JNEUROSCI.0730-19.2019.
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