The McLean Hospital Brain Bank receives new NIH contract

The Harvard Brain Tissue Resource Center at McLean Hospital, known as the Brain Bank, has received a new contract from the National Institutes of Health (NIH) for a total of $12,796,394.

The McLean Hospital Brain Bank is proud to be one of six brain banks that are part of the NIH NeuroBioBank, a national resource for investigators who use postmortem brain tissue and related biospecimens in their research. Since its inception in 1978, the Brain Bank has collected over 9,000 human brain specimens from donors with a variety of neurological and psychiatric disorders as well as from healthy controls.

The new funds will be dispersed over the course of five years under contract 75N95019C00046 from September 1, 2019, through August 31, 2020, with four option years. The funds will be dispensed over time with future year funding dependent on the previous year's performance and funds availability.

The Brain Bank's previous NIH contract, which ran from 2013 to 2019, funded the collection of 100 brains per year. The center's new contract will fund 180 brains per year and allow for several new procedures to enhance the center's mission. The NIH NeuroBioBank has been funded in whole or in part with federal funds from the National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development, and National Institute on Aging.

Research on samples from donors with brain disorders allows us to understand what changes occur in the brains of people who suffer from these conditions and to help develop effective therapies."
Sabina Berretta, MD, director of McLean Hospital's Brain Bank and the Translational Neuroscience Laboratory

Berretta adds that deepening the understanding of the brain pathology of psychiatric disorders also helps combat stigma. "Psychiatric disorders are often mistakenly understood as 'psychological' or 'behavioral' disorders: conditions without a biological underpinning. This erroneous view leads to the stigma associated with these disorders, which are often seen as character flaws as opposed to what they really are, disorders of the brain--no different than disorders that affect other organs, such as heart conditions."

The Brain Bank gratefully accepts brain donations from people diagnosed with various brain disorders, such as depression, multiple sclerosis, and Tourette syndrome, as well as from individuals who are not affected by these conditions. The new NIH contract includes a mandate to recover brain donations from people who suffered from substance misuse - particularly opioid use disorder - and from those who died of opioid overdose.

Tissues from donors not affected by brain disorders are the most requested samples from the Brain Bank and are included in the highest number of studies. "It is equally important that people who do not suffer from brain disorders consider registering to become brain donors," Berretta said. "Any study on any brain disorder needs a comparison group, and samples from people who did not have brain disorders can provide a necessary baseline."

Becoming a prospective brain tissue donor is easy. Any person 18 years of age or older can contact the Brain Bank at 800.BRAIN.BANK (800.272.4622) to learn more about registering to become a donor. The identity of each registered donor will remain strictly confidential. More information and a registration form can be found online.

Each donation is "truly a gift that keeps on giving," Berretta said, since tissue from one brain is included in hundreds of different studies.

"A brain donation allows our society to improve the human condition by improving treatment of debilitating and common disorders," she said. "The more we study the human brain, particularly using the powerful technological approaches available in recent years, the more we can understand ourselves."

McLean Hospital